microvascular disease and PAD had a 23-fold increase in the risk of lower limb amputation which accounted for 45% of all amputations.PAD had a 13.9-fold increased risk of lower limb amputation and suffered 22% of all amputations.microvascular disease had a 3.7-fold increased risk of lower limb amputation, and experienced 18% of all amputations during the study. Over an average of nine years, participants with: Researchers used data from the Veterans Aging Cohort Study, which included more than 125,000 veterans who initially did not have amputations when the study began. Department of Veterans Affairs, examined amputation risk among people with microvascular disease or peripheral artery disease (PAD) or those who had both microvascular disease and PAD. The study, funded by the American Heart Association Strategically Focused Research Network in Vascular Disease and the U.S. ET Monday, July 8, 2019ĭALLAS, JMicrovascular disease is independently associated with a higher risk of leg amputation compared to people without the disease, according to new research in the American Heart Association’s journal Circulation. Study participants with both microvascular disease and peripheral arterial disease (PAD) had an almost 23-fold increased risk of amputation compared to those without any vascular disease.Įmbargoed until 4 a.Microvascular disease, a disorder of very small blood vessels, may increase the risk of leg amputation independent of other blood vessel conditions and regardless of the location of the microvascular issue, such as eyes (retinopathy), kidneys (nephropathy) or feet (neuropathy).
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